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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B5
All Species:
13.94
Human Site:
S610
Identified Species:
25.56
UniProt:
Q13144
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13144
NP_003898.2
721
80380
S610
F
P
L
Q
Q
M
D
S
P
L
D
S
S
R
Y
Chimpanzee
Pan troglodytes
XP_001139517
721
80405
S610
F
P
L
Q
Q
M
D
S
P
L
D
S
S
R
Y
Rhesus Macaque
Macaca mulatta
XP_001104122
721
80584
S610
F
P
L
Q
Q
M
D
S
P
L
D
S
S
R
Y
Dog
Lupus familis
XP_545227
721
80416
S610
F
P
L
Q
Q
M
D
S
L
L
D
P
N
R
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHW4
717
80068
G606
F
P
L
Q
Q
V
D
G
L
L
D
P
N
R
Y
Rat
Rattus norvegicus
Q64350
716
80188
G605
F
P
L
Q
Q
V
D
G
V
L
D
P
N
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506973
657
73984
W562
L
L
P
L
L
K
A
W
S
P
V
F
K
N
Y
Chicken
Gallus gallus
XP_422755
716
81293
A594
F
P
L
Q
Q
L
D
A
N
L
D
S
Q
N
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001107069
703
79791
V593
F
P
L
H
Q
Q
G
V
E
I
T
T
A
Q
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784928
1190
133261
G1078
M
P
H
L
K
A
S
G
P
L
S
S
Q
Q
L
Poplar Tree
Populus trichocarpa
XP_002328528
718
80680
A612
Q
A
L
E
I
P
H
A
T
A
G
E
L
R
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_181042
730
81845
N612
L
A
L
D
T
P
H
N
S
G
S
E
L
Y
K
Baker's Yeast
Sacchar. cerevisiae
P32501
712
81143
T602
R
V
Y
H
F
I
A
T
Q
T
L
G
P
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.3
93.1
N.A.
88.3
88.3
N.A.
77.2
73.2
N.A.
62.9
N.A.
N.A.
N.A.
N.A.
27.2
Protein Similarity:
100
99.8
99
96.2
N.A.
93.4
93.9
N.A.
83.7
85.3
N.A.
78.5
N.A.
N.A.
N.A.
N.A.
40
P-Site Identity:
100
100
100
80
N.A.
66.6
66.6
N.A.
6.6
66.6
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
86.6
N.A.
80
80
N.A.
6.6
80
N.A.
60
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
33.8
N.A.
N.A.
32.7
28.8
N.A.
Protein Similarity:
55.2
N.A.
N.A.
53.2
50
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
8
16
16
0
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
54
0
0
0
54
0
0
0
8
% D
% Glu:
0
0
0
8
0
0
0
0
8
0
0
16
0
0
0
% E
% Phe:
62
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
24
0
8
8
8
0
0
0
% G
% His:
0
0
8
16
0
0
16
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
8
0
0
0
0
0
0
8
8
16
% K
% Leu:
16
8
77
16
8
8
0
0
16
62
8
0
16
0
8
% L
% Met:
8
0
0
0
0
31
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
8
0
0
0
24
16
0
% N
% Pro:
0
70
8
0
0
16
0
0
31
8
0
24
8
0
0
% P
% Gln:
8
0
0
54
62
8
0
0
8
0
0
0
16
16
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
0
0
0
54
0
% R
% Ser:
0
0
0
0
0
0
8
31
16
0
16
39
24
0
0
% S
% Thr:
0
0
0
0
8
0
0
8
8
8
8
8
0
0
0
% T
% Val:
0
8
0
0
0
16
0
8
8
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
70
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _